James Cook University shapes this race, with the Social Sciences Building serving as the start and finish and James Cook Drive guiding the initial miles. The Townsville 10 Miler Run is Townsville Road Runners' signature 10-mile event, a road and paved path course that offers a club race feel with sufficient challenge for consistently trained runners.
The long course follows a scenic loop through the JCU campus, extending along Discovery Drive, then entering the Ross River section where the running becomes more engaging with footbridges, tunnels under Riverside Boulevard, and tranquil riverside paths past Aplins Weir and Gleesons Weir. Crossing the Federation Bridge marks a key point before the return via Parkinson Road, while the shorter campus course is suitable for beginners, newcomers, or those looking to test their speed on a cool morning.