The Ville to Ville Relay covers 72 miles from Asheville, North Carolina, to Greenville, South Carolina. Teams start before dawn in the mountains and finish at Hampton Station. This point-to-point road relay is for runners 21 and older, typically held in April. Three to six people share the effort over 12 legs, each between 3 and 9 miles.
The route descends from the Appalachian peaks into the foothills, passing through southern towns and past breweries instead of a closed city loop. Each team uses its own vehicle to manage runner handoffs, making the day feel like both a race and a road trip. The finish in Greenville includes music, food, and craft beer. The series also offers shorter or coastal options for teams seeking a different format.